GANA PATCH

GANA PATCH is a bio-cellulose sheet containing cross-linked hyaluronic acid. Its main use is the covering of open wounds. Bacterial cellulose is non-allergenic and does not cause inflammation in the body.

Development objective: a wound-covering material for patients with widespread skin damage, who until now have been very hard to treat.

• As soon as it is applied, GANA PATCH keeps the wound moist by preventing evaporation
• Prevents infection
• Mechanical and chemical protection
• Absorbs exudate
• Reduces pain
• Components of GANA PATCH stimulate collagen synthesis in the soft-tissue defect, so exudate stops
• The high-concentration cross-linked hyaluronic acid gel absorbs watery content from the wound
• Fills the soft-tissue defect immediately and keeps it moist
• No need to change the dressing every day: change GANA PATCH every week
• For major wounds with soft-tissue loss and epithelial damage, GANA PATCH includes active ingredients for epithelial-cell and soft-tissue regeneration

• Skin graft not necessary: after immediate application, skin function recovers from burns or skin loss
• Regeneration of soft tissue and epithelium: the bio-cellulose itself replaces soft tissue mechanically
• No further wound dressing necessary: once applied, the wound is simply observed until it has healed
• Progress: bio-cellulose causes no immune side effect or other response in the body; epithelial cells migrate onto GANA PATCH, which may then be positioned under the epidermis

• Able to resist infection
• Able to prevent water loss
• Able to withstand shear forces
• Cost-effective
• Widely available
• Long shelf life and easy to store
• Lack of antigenicity
• Flexible in thickness
• Durable, with long-term wound stability
• Conforms to irregular wound surfaces and is easy to secure and apply

Bacterial cellulose is an organic compound with the formula (C₆H₁₀O₅)n produced by certain bacteria, principally of the genera Acetobacter, Sarcina ventriculi and Agrobacterium. It differs from plant cellulose in its high purity, strength, mouldability and increased water-holding ability, and by controlling the synthesis it can be tailored to specific properties. Historically limited to nata de coco, it is now used in textiles, cosmetics, food products and medical applications.

SEM findings: the aperture of bacterial cellulose is so small that cells and bacteria cannot pass through it, only water, and its surface area is so wide that the bio-cellulose holds a large amount of water. In conclusion, bio-cellulose protects against infection, absorbs exudate from the wound and lets water evaporate outward.

Hyaluronic acid (hyaluronan) is an anionic, non-sulfated glycosaminoglycan distributed widely through connective, epithelial and neural tissues. It is unique among glycosaminoglycans in being non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large, with a molecular weight often in the millions. As one of the chief components of the extracellular matrix it contributes to cell proliferation and migration. The average 70 kg person has roughly 15 g of hyaluronan in the body, one third of which is turned over every day.

1. Sterilise the wound
2. Take the GANA PATCH sheet out of the bottle, using sterile technique
3. Cover the wound with the GANA PATCH sheet
4. Cover the sheet with sterile gauze
5. Change GANA PATCH every week

The wound does not need to be cleaned every day; just check whether there is any sign of infection.